How can I stop Itunes from opening by itself?

Itunes keep opening by itself and it's getting pretty irritating at this point. I haven't purposefully gone into it in days, but it keeps popping up and starting to play music anyway. I quit it every time, but then, sooner or later, the same thing happens again.
I've done some searching to see if I could find any solutions, but the suggestions I've found haven't done anything. For one, I took "Itunes Helper" off of my "Login Items" under my account, but that didn't do any good. I also checked to see if I have any Itunes widgets running on the dashboard and I don't. I even disabled the Itunes widget. I've read that other programs could be opening it, but I don't have any new programs on my computer, so if this wasn't occurring before because of something else, I don't know why it would be now.
This is kind of driving me insane, so any help would be greatly appreciated. Thanks in advance.
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Pure guesswork, but when I had problems with iTunes launching again and again, the reason were my external speakers. I simply had to unplug the speakers  from the line-out socket, and iTunes stopped launching on its own.